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D′Amour, utilizing prepuberal rats, was unable to verify the results of Ludwigand von Ries. Hechter, Lev and Soskin, whereas studying the relation of hyperemia to estrin motion, declare that yohimbine alone was able to producing an estrous response in castrate mice. D′Amour was unable to obtain cornification of the vaginal epithelium of castrated rats. Tribulus terrestris is a flowering plant belongs to the household Zygophyllaceae, native to heat temperate and tropical regions. Administration of TT to humans and animals improves libido and spermatogenesis. Terrestris steroid saponins possess neither direct nor indirect androgen-increasing properties.

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